Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

Cerebral ischaemia/reperfusion (CI/R) injury is a major challenge due to the lack of effective neuroprotective drugs. Hederagenin (HE) is the aglycone part of saponins extracted from Hedera helix Linné that has exhibited anti-apoptotic and anti-inflammatory effects; however, the role of HE in CI/R h...

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Vydáno v:Front Pharmacol
Hlavní autoři: Yu, Hailong, Song, Lilong, Cao, Xiang, Li, Wei, Zhao, Yuanyuan, Chen, Jian, Li, Jun, Chen, Yingzhu, Yu, Wenkui, Xu, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406912/
https://ncbi.nlm.nih.gov/pubmed/32848779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01173
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