Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells

Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. Protein kinase CK2 phosphorylates the N-terminus of isoform ECE1c, enhancing...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Pérez-Moreno, Pablo, Quezada-Meza, Camila, Chavez-Almarza, Cristopher, Niechi, Ignacio, Silva-Pavez, Eduardo, Trigo-Hidalgo, César, Aguayo, Francisco, Jara, Lilian, Cáceres-Verschae, Albano, Varas-Godoy, Manuel, Díaz, Víctor M., García de Herreros, Antonio, Burzio, Verónica A., Tapia, Julio C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406796/
https://ncbi.nlm.nih.gov/pubmed/32850305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01004
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