A replication-competent late liver stage–attenuated human malaria parasite

Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite (GAP) strains for vaccination. Using rodent malaria parasites, w...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Goswami, Debashree, Betz, William, Locham, Navin K., Parthiban, Chaitra, Brager, Carolyn, Schäfer, Carola, Camargo, Nelly, Nguyen, Thao, Kennedy, Spencer Y., Murphy, Sean C., Vaughan, Ashley M., Kappe, Stefan H.I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406309/
https://ncbi.nlm.nih.gov/pubmed/32484795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135589
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