Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy

Mechanisms of chimeric antigen receptor (CAR) T cell–mediated antitumor immunity and toxicity remain poorly characterized because few studies examine the intact tumor microenvironment (TME) following CAR T cell infusion. Axicabtagene ciloleucel is an autologous anti-CD19 CAR T cell therapy approved...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Chen, Pei-Hsuan, Lipschitz, Mikel, Weirather, Jason L., Jacobson, Caron, Armand, Philippe, Wright, Kyle, Hodi, F. Stephen, Roberts, Zachary J., Sievers, Stuart A., Rossi, John, Bot, Adrian, Go, William, Rodig, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406247/
https://ncbi.nlm.nih.gov/pubmed/32484797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134612
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