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Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2

AIMS: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly through binding to angiotensin converting enzyme 2 (ACE2) via its S-protein. Genetic analysis of (ACE2) gene revealed several variants that...

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Dettagli Bibliografici
Pubblicato in:Life Sci
Autori principali: Mohammad, Anwar, Marafie, Sulaiman K., Alshawaf, Eman, Abu-Farha, Mohamed, Abubaker, Jehad, Al-Mulla, Fahd
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Authors. Published by Elsevier Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7405906/
https://ncbi.nlm.nih.gov/pubmed/32768580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2020.118219
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