Preconditioning with rHMGB1 ameliorates lung ischemia–reperfusion injury by inhibiting alveolar macrophage pyroptosis via the Keap1/Nrf2/HO-1 signaling pathway

BACKGROUND: Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-dependent macrophage pyroptosis contributes to organ damage caused by ischemia/reperfusion injury. Oxidative stress and antioxidant enzymes also play an im...

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Vydáno v:J Transl Med
Hlavní autoři: Fei, Lin, Jingyuan, Xiao, Fangte, Liang, Huijun, Dai, Liu, Ye, Ren, Jing, Jinyuan, Lin, Linghui, Pan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7405465/
https://ncbi.nlm.nih.gov/pubmed/32758258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02467-w
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