The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

A common missense variant in SLC39A8 is convincingly associated with schizophrenia and several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in undetectable serum manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sensitivity of glyc...

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Publicado no:Sci Rep
Main Authors: Mealer, Robert G., Jenkins, Bruce G., Chen, Chia-Yen, Daly, Mark J., Ge, Tian, Lehoux, Sylvain, Marquardt, Thorsten, Palmer, Christopher D., Park, Julien H., Parsons, Patrick J., Sackstein, Robert, Williams, Sarah E., Cummings, Richard D., Scolnick, Edward M., Smoller, Jordan W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403432/
https://ncbi.nlm.nih.gov/pubmed/32753748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70108-9
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