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Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus
Lentivirus vectors (LVs) are efficient tools for gene transfer, but the non-specific nature of transgene integration by the viral integration machinery carries an inherent risk for genotoxicity. We modified the integration machinery of LVs and harnessed the cellular DNA double-strand break repair ma...
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| Publicado en: | Mol Ther |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Gene & Cell Therapy
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7403359/ https://ncbi.nlm.nih.gov/pubmed/32504545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.05.019 |
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