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Computational identification of disulfiram and neratinib as putative SARS-CoV-2 main protease inhibitors

Identification of disulfiram and neratinib as putative covalent inhibitors of SARS-CoV-2 virus main protease M(pro) by a combination of ‘on-top docking’ procedure, expert evaluation of potential hits and molecular dynamics is reported herein. This finding shows the importance of further development...

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Veröffentlicht in:Mendeleev Communications
Hauptverfasser: Stroylov, Victor S., Svitanko, Igor V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402654/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mencom.2020.07.004
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