High Mobility Group Box-1 Induces Pro-Inflammatory Signaling in Human Nucleus Pulposus Cells via Toll-Like Receptor 4-Dependent Pathway

Intervertebral disc (IVD) degeneration (DD) is associated with low back pain, the leading cause of disability worldwide. Damage-associated molecular patterns (DAMPs) that contribute to inflammation and trigger DD have not been well characterized. Extracellular high mobility group box-1 (HMGB1) prote...

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Publicat a:J Orthop Res
Autors principals: Shah, Bhranti S., Burt, Kevin G., Jacobsen, Timothy, Fernandes, Tiago D., Alipui, Didier Olivier, Weber, Kathryn T., Levine, Mitchell, Chavan, Sangeeta S., Yang, Huan, Tracey, Kevin J., Chahine, Nadeen O.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401857/
https://ncbi.nlm.nih.gov/pubmed/30273982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.24154
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