Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling

PURPOSE: Cone photoreceptor function loss 3 (Gnat2(cpfl3/cpfl3) or cpfl3) is a mouse model commonly used as a functional cones null from a naturally occurring mutation in the α-subunit of cone transducin (Gnat2). We nevertheless detected robust cone-mediated light responses from cpfl3 animals, which...

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Dades bibliogràfiques
Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Chen, Natalie S., Ingram, Norianne T., Frederiksen, Rikard, Sampath, Alapakkam P., Chen, Jeannie, Fain, Gordon L.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2020
Matèries:
Visual Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401474/
https://ncbi.nlm.nih.gov/pubmed/32315379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.4.26
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