53. TUCATINIB VS PLACEBO ADDED TO TRASTUZUMAB AND CAPECITABINE FOR PATIENTS WITH PREVIOUSLY TREATED HER2+ METASTATIC BREAST CANCER (MBC) WITH BRAIN METASTASES (BM) (HER2CLIMB)

BACKGROUND: HER2CLIMB (NCT02614794) primary results have been reported previously (Murthy, NEJM 2019). We report results of exploratory efficacy analyses in pts with brain metastases (BM). METHODS: All HER2+ MBC pts enrolled had a baseline brain MRI. Pts with BM were eligible and randomized 2:1 to r...

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Bibliographic Details
Published in:Neurooncol Adv
Main Authors: Lin, Nancy, Murthy, Rashmi, Anders, Carey, Borges, Virginia, Hurvitz, Sara, Loi, Sherene, Abramson, Vandana, Bedard, Philippe, Oliveira, Mafalda, Zelnack, Amelia, DiGiovanna, Michael, Bachelot, Thomas, Chien, A Jo, O’Regan, Ruth, Wardley, Andrew, Mueller, Volkmar, Carey, Lisa, McGoldrick, Suzanne, An, Xuebei, Winer, Eric
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401403/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa073.041
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