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Enhancement of piperlongumine chemosensitivity by silencing heme oxygenase-1 expression in cholangiocarcinoma cell lines

Piperlongumine (PL) produces reactive oxygen species (ROS) and induces G2/M-phase arrest in cholangiocarcinoma (CCA) cells via the JNK/ERK pathway. A differential response to PL was observed among all CCA cell lines However, the underlying mechanisms have remained to be fully elucidated. The aim of...

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Pubblicato in:Oncol Lett
Autori principali: Talabnin, Chutima, Talabnin, Krajang, Wongkham, Sopit
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400959/
https://ncbi.nlm.nih.gov/pubmed/32782567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.11784
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