Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway

Vascular endothelium dysfunction plays a pivotal role in the initiation and progression of multiple organ dysfunction. The mesenchymal stem cell (MSC) maintains vascular endothelial barrier survival via secreting bioactive factors. However, the mechanism of human umbilical cord MSC (hMSC) in protect...

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Publicado no:iScience
Main Authors: Liu, Lingying, Yin, Huinan, Hao, Xingxia, Song, Huifeng, Chai, Jiake, Duan, Hongjie, Chang, Yang, Yang, Longlong, Wu, Yushou, Han, Shaofang, Wang, Xiaoteng, Yue, Xiaotong, Chi, Yunfei, Liu, Wei, Wang, Qiong, Wang, Hongyu, Bai, Hailiang, Shi, Xiuxiu, Li, Shaozeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399190/
https://ncbi.nlm.nih.gov/pubmed/32745988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101383
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