Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis

Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition, differential thermosensitivity, and synergy with existing antifunga...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Autores principales: Perlatti, Bruno, Nichols, Connie B., Lan, Nan, Wiemann, Philipp, Harvey, Colin J. B., Alspaugh, J. Andrew, Bills, Gerald F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399079/
https://ncbi.nlm.nih.gov/pubmed/32849391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01766
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