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A highly processive actinobacterial topoisomerase I – thoughts on Streptomyces’ demand for an enzyme with a unique C-terminal domain

Topoisomerase I (TopA) is an essential enzyme that is required to remove excess negative supercoils from chromosomal DNA. Actinobacteria encode unusual TopA homologues with a unique C-terminal domain that contains lysine repeats and confers high enzyme processivity. Interestingly, the longest stretc...

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Detalhes bibliográficos
Publicado no:Microbiology (Reading)
Main Authors: Szafran, Marcin J., Strzałka, Agnieszka, Jakimowicz, Dagmara
Formato: Artigo
Idioma:Inglês
Publicado em: Microbiology Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398561/
https://ncbi.nlm.nih.gov/pubmed/31390324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.000841
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