PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mT...

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Podrobná bibliografie
Vydáno v:Genes (Basel)
Hlavní autoři: Fusco, Nicola, Sajjadi, Elham, Venetis, Konstantinos, Gaudioso, Gabriella, Lopez, Gianluca, Corti, Chiara, Rocco, Elena Guerini, Criscitiello, Carmen, Malapelle, Umberto, Invernizzi, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397204/
https://ncbi.nlm.nih.gov/pubmed/32605290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11070719
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