Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels

Chronic low-grade inflammation plays an important role in the pathogenesis of type 2 diabetes. Src homology 2 domain-containing tyrosine phosphatase-2 (SHP2) has been reported to play diverse roles in different tissues during the development of metabolic disorders. We previously reported that SHP2 i...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Liu, Wen, Yin, Ye, Wang, Meijing, Fan, Ting, Zhu, Yuyu, Shen, Lihong, Peng, Shuang, Gao, Jian, Deng, Guoliang, Meng, Xiangbao, Kong, Lingdong, Feng, Gen-Sheng, Guo, Wenjie, Xu, Qiang, Sun, Yang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397102/
https://ncbi.nlm.nih.gov/pubmed/32546483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011840
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