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Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer

Highly heterogenous cancers, such as triple-negative breast cancer (TNBC), remain challenging immunotherapeutic targets. Herein, we describe the synthesis and evaluation of immunotherapeutic liposomal spherical nucleic acids (SNAs) for TNBC therapy. The SNAs comprise immunostimulatory oligonucleotid...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Callmann, Cassandra E., Cole, Lisa E., Kusmierz, Caroline D., Huang, Ziyin, Horiuchi, Dai, Mirkin, Chad A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395518/
https://ncbi.nlm.nih.gov/pubmed/32669433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005794117
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