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Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations

Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through experimental evolution in a microfluidics-based turbidostat, we demonstrate that antibiotic-resistant...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Melnikov, Sergey V., Stevens, David L., Fu, Xian, Kwok, Hui Si, Zhang, Jin-Tao, Shen, Yue, Sabina, Jeffery, Lee, Kevin, Lee, Harry, Söll, Dieter
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395499/
https://ncbi.nlm.nih.gov/pubmed/32661175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003132117
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