SERCA overexpression reduces reperfusion-mediated cardiac microvascular damage through inhibition of the calcium/MCU/mPTP/necroptosis signaling pathways

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated by dysregulated intracellular calcium signals. Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) functions to...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Li, Chen, Ma, Qinghui, Toan, Sam, Wang, Jin, Zhou, Hao, Liang, Jianqiu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395441/
https://ncbi.nlm.nih.gov/pubmed/32738788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101659
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