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Developing oncolytic Herpes simplex virus type 1 through UL39 knockout by CRISPR-Cas9
OBJECTIVE(S): Oncolytic Herpes simplex virus type 1 (HSV-1) has emerged as a promising strategy for cancer therapy. However, development of novel oncolytic mutants has remained a major challenge owing to low efficiency of conventional genome editing methods. Recently, CRISPR-Cas9 has revolutionized...
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| Publicado no: | Iran J Basic Med Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mashhad University of Medical Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7395182/ https://ncbi.nlm.nih.gov/pubmed/32774817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2020.43864.10286 |
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