Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis

SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated ne...

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Vydáno v:J Neurosci
Hlavní autoři: Stupack, Jessica, Xiong, Xiao-Peng, Jiang, Lu-Lin, Zhang, Tongmei, Zhou, Lisa, Campos, Alex, Ranscht, Barbara, Mobley, William, Pasquale, Elena B., Xu, Huaxi, Huang, Timothy Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392511/
https://ncbi.nlm.nih.gov/pubmed/32601248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0723-20.2020
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