DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression

The loss of cancer-cell junctions and escape from the primary-tumor microenvironment are hallmarks of metastasis. A tight-junction protein, Claudin 1 (CLDN1), is a metastasis suppressor in lung adenocarcinoma. However, as a metastasis suppressor, the underlying molecular mechanisms of CLDN1 has not...

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Publicado en:Theranostics
Autores principales: Wu, Jia-En, Wu, Yi-Ying, Tung, Chia-Hao, Tsai, Yao-Tsung, Chen, Hsuan-Yu, Chen, Yuh-Ling, Hong, Tse-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392003/
https://ncbi.nlm.nih.gov/pubmed/32754286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45785
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