Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis

Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived macrophages (MDM) in the lung. Infected macrophages then upregulate effector functio...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cox, Donal J., Coleman, Amy M., Gogan, Karl M., Phelan, James J., Ó Maoldomhnaigh, Cilian, Dunne, Pádraic J., Basdeo, Sharee A., Keane, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7390906/
https://ncbi.nlm.nih.gov/pubmed/32793237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01609
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