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利用CRISPR/Cas9构建甲基丙二酸血症cblC型W203X突变小鼠模型
OBJECTIVE: To construct a W203X-mutant mouse model of cblC type methylmalonic acidemia based on the CRISPR/Cas9 technology. METHODS: At first, BLAST was used to compare the conservative nature of the cblC gene and protein sequences in humans and mice, and then, the CRISPR/Cas9 technology was used fo...
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| Yayımlandı: | Zhongguo Dang Dai Er Ke Za Zhi |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
中国当代儿科杂志编辑部
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7389904/ https://ncbi.nlm.nih.gov/pubmed/31416510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7499/j.issn.1008-8830.2019.08.016 |
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