Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying mechanisms when using either germ-free (GF) housing conditions or treatments with antibiotics (ABX) remained unknown. In this study, we show that GF and...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Mezö, Charlotte, Dokalis, Nikolaos, Mossad, Omar, Staszewski, Ori, Neuber, Jana, Yilmaz, Bahtiyar, Schnepf, Daniel, de Agüero, Mercedes Gomez, Ganal-Vonarburg, Stephanie C., Macpherson, Andrew J., Meyer-Luehmann, Melanie, Staeheli, Peter, Blank, Thomas, Prinz, Marco, Erny, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7389451/
https://ncbi.nlm.nih.gov/pubmed/32727612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00988-5
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