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Lapatinib-induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro

The present study was designed to ascertain whether lapatinib, a tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), affects ovarian reserve and fertility potential in a mouse model. Female C57BL/6 mice were treated with either vehicle or lapatinib (100 or 200 mg/kg/day orally) for...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncol Rep
Prif Awduron: Liao, Qiuyue, Feng, Xue, Li, Xi, Chen, Ge, Chen, Jing, Yang, Bin, Li, Kezhen, Ai, Jihui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: D.A. Spandidos 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388577/
https://ncbi.nlm.nih.gov/pubmed/32582968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2020.7660
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