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Clinical, biochemical, and genetic analysis of a Chinese Han pedigree with holocarboxylase synthetase deficiency: a case report

BACKGROUND: Holocarboxylase synthetase (HLCS) deficiency is a rare inborn disorder of biotin metabolism, which results in defects in several biotin-dependent carboxylases and presents with metabolic ketoacidosis and skin lesions. CASE PRESENTATION: In this paper, we report a Chinese Han pedigree wit...

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Detalhes bibliográficos
Publicado no:BMC Med Genet
Main Authors: Zheng, Zhenzhu, Yuan, Gaopin, Zheng, Minyan, Lin, Yiming, Zheng, Faming, Jiang, Mengyi, Zhu, Lin, Fu, Qingliu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388215/
https://ncbi.nlm.nih.gov/pubmed/32727382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-020-01080-4
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