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α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages

Hemolysin expressing UPEC strains have been associated with severe advanced kidney pathologies, such as cystitis and pyelonephritis, which are associated with an inflammatory response. Macrophages play an important role in regulating an inflammatory response during a urinary tract infection. We have...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Verma, Vivek, Kumar, Parveen, Gupta, Surbhi, Yadav, Sonal, Dhanda, Rakesh Singh, Thorlacius, Henrik, Yadav, Manisha
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387347/
https://ncbi.nlm.nih.gov/pubmed/32724079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69501-1
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