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Model-based optimization of combination protocols for irradiation-insensitive cancers
Alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. In this theoretical study we search for the best protocols combining targeted therapy with radiation to treat cancers with wild-type p53, but having downregulated expression of PTEN or ov...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7387345/ https://ncbi.nlm.nih.gov/pubmed/32724100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69380-6 |
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