Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a condition involving disruption of the bone tissue distribution. Nucleus pulposus mesenchymal stem cells (NPMSCs) and Sirtuin 1 (SIRT1) play important roles in bone diseases, therefore the aim of the present study was to evaluate the roles of SIRT1 and NPMS...

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Pubblicato in:Int J Mol Med
Autori principali: Ou, Xuancheng, Ying, Jinwei, Bai, Xuedong, Wang, Chaofeng, Ruan, Dike
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387093/
https://ncbi.nlm.nih.gov/pubmed/32705163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2020.4668
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