Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

RATIONALE: Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow the transport of glucose to the surrounding tissues. GLUT1 (glucose transporter isoform 1/Slc2a1) is highly exp...

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Published in:Circ Res
Main Authors: Veys, Koen, Fan, Zheng, Ghobrial, Moheb, Bouché, Ann, García-Caballero, Melissa, Vriens, Kim, Conchinha, Nadine Vasconcelos, Seuwen, Aline, Schlegel, Felix, Gorski, Tatiane, Crabbé, Melissa, Gilardoni, Paola, Ardicoglu, Raphaela, Schaffenrath, Johanna, Casteels, Cindy, De Smet, Gino, Smolders, Ilse, Van Laere, Koen, Abel, E. Dale, Fendt, Sarah-Maria, Schroeter, Aileen, Kalucka, Joanna, Cantelmo, Anna Rita, Wälchli, Thomas, Keller, Annika, Carmeliet, Peter, De Bock, Katrien
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386868/
https://ncbi.nlm.nih.gov/pubmed/32404031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.316463
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