Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation

Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma (L-CTCL) that arises from malignant clonally derived skin-homing CD4(+) T cells. Based on advancements in our understanding of the mechanisms underlying L-CTCL, boosting the suppressed immune response emerges as a pr...

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Publicado no:Oncoimmunology
Main Authors: Saulite, Ieva, Ignatova, Desislava, Chang, Yun-Tsan, Fassnacht, Christina, Dimitriou, Florentia, Varypataki, Eleni, Anzengruber, Florian, Nägeli, Mirjam, Cozzio, Antonio, Dummer, Reinhard, Scarisbrick, Julia, Pascolo, Steve, Hoetzenecker, Wolfram, Bobrowicz, Malgorzata, Guenova, Emmanuella
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386859/
https://ncbi.nlm.nih.gov/pubmed/32760603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1738797
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