Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin

BACKGROUND AND AIM: Flibanserin (FLB) is a multifunctional serotonergic agent used for treating hypoactive sexual desire disorder in premenopausal women via oral administration. FLB has a reported limited oral bioavailability of 33% that could be attributed to the drug’s first-pass metabolism. In ad...

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Bibliografiske detaljer
Udgivet i:Int J Nanomedicine
Main Authors: Fahmy, Usama A, Ahmed, Osama A A, Badr-Eldin, Shaimaa M, Aldawsari, Hibah M, Okbazghi, Solomon Z, Awan, Zuhier A, Bakhrebah, Muhammed A, Alomary, Mohammad N, Abdulaal, Wesam H, Medina, Carlos, Alhakamy, Nabil A
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386805/
https://ncbi.nlm.nih.gov/pubmed/32801690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S258791
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