Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis

Yeast and fast-growing human tumor cells share metabolic similarities in that both cells use fermentation of glucose for energy and both are highly sensitive to the glucose analog 2-deoxyglucose. Spontaneous mutations in S. cerevisiae that conferred resistance to 2-deoxyglucose were identified by wh...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Soncini, Samantha R., Chandrashekarappa, Dakshayini G., Augustine, David A., Callahan, Kenny P., O’Donnell, Allyson F., Schmidt, Martin C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386655/
https://ncbi.nlm.nih.gov/pubmed/32673313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008484
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