De novo design of modular and tunable allosteric biosensors

Naturally occurring allosteric protein switches have been repurposed for developing novel biosensors and reporters for cellular and clinical applications (1) , but the number of such switches is limited, and engineering them is often challenging as each is different. Here, we show that a very genera...

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Pubblicato in:bioRxiv
Autori principali: Quijano-Rubio, Alfredo, Yeh, Hsien-Wei, Park, Jooyoung, Lee, Hansol, Langan, Robert A., Boyken, Scott E., Lajoie, Marc J., Cao, Longxing, Chow, Cameron M., Miranda, Marcos C., Wi, Jimin, Hong, Hyo Jeong, Stewart, Lance, Oh, Byung-Ha, Baker, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386493/
https://ncbi.nlm.nih.gov/pubmed/32743576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.18.206946
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