Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

OBJECTIVES: Determine global skin transcriptome patterns of early diffuse systemic sclerosis (SSc) and how they differ from later disease. METHODS: Skin biopsy RNA from 48 patients in the Prospective Registry for Early Systemic Sclerosis (PRESS) cohort (mean disease duration 1.3 years) and 33 matche...

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Vydáno v:Ann Rheum Dis
Hlavní autoři: Skaug, Brian, Khanna, Dinesh, Swindell, William R, Hinchcliff, Monique E, Frech, Tracy M, Steen, Virginia D, Hant, Faye N, Gordon, Jessica K, Shah, Ami A, Zhu, Lisha, Zheng, W Jim, Browning, Jeffrey L, Barron, Alexander M S, Wu, Minghua, Visvanathan, Sudha, Baum, Patrick, Franks, Jennifer M, Whitfield, Michael L, Shanmugam, Victoria K, Domsic, Robyn T, Castelino, Flavia V, Bernstein, Elana J, Wareing, Nancy, Lyons, Marka A, Ying, Jun, Charles, Julio, Mayes, Maureen D, Assassi, Shervin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386329/
https://ncbi.nlm.nih.gov/pubmed/31767698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-215894
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