MEK blockade overcomes the limited activity of palbociclib in head and neck cancer

Head and neck cancer (HNC) is characterized with multiple aberrations in cell cycle pathways, including amplification of cyclin D1. Palbociclib (PAL), a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, has been reported to regulate cell cycle progression in HNC. However, recent studies have revealed...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Fang, Zhenghuan, Jung, Kyung Hee, Lee, Ji Eun, Cho, Jinhyun, Lim, Joo Han, Hong, Soon-Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385517/
https://ncbi.nlm.nih.gov/pubmed/32712554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100833
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