The loss of Bcl-6 expressing T follicular helper cells and the absence of germinal centers in COVID-19

Humoral responses in COVID-19 disease are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers, a striking re...

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Detalhes bibliográficos
Publicado no:SSRN
Main Authors: Kaneko, Naoki, Kuo, Hsiao-Hsuan, Boucau, Julie, Farmer, Jocelyn R., Allard-Chamard, Hugues, Mahajan, Vinay S., Piechocka-Trocha, Alicja, Lefteri, Kristina, Osborn, Matt, Bals, Julia, Bartsch, Yannic C., Bonheur, Nathalie, Caradonna, Timothy M., Chevalier, Josh, Chowdhury, Fatema, Diefenbach, Thomas J., Einkauf, Kevin, Fallon, Jon, Feldman, Jared, Finn, Kelsey K., Garcia-Broncano, Pilar, Hartana, Ciputra Adijaya, Hauser, Blake M., Jiang, Chenyang, Kaplonek, Paulina, Karpell, Marshall, Koscher, Eric C., Lian, Xiaodong, Liu, Hang, Liu, Jinqing, Ly, Ngoc L., Michell, Ashlin R., Rassadkina, Yelizaveta, Seiger, Kyra, Sessa, Libera, Shin, Sally, Singh, Nishant, Sun, Weiwei, Sun, Xiaoming, Ticheli, Hannah J., Waring, Michael T., Zhu, Alex L., Li, Jonathan, Lingwood, Daniel, Schmidt, Aaron G., Lichterfeld, Matthias, Walker, Bruce D., Yu, Xu, Padera, Robert F, Pillai, Shiv
Formato: Artigo
Idioma:Inglês
Publicado em: Social Science Electronic Publishing 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385482/
https://ncbi.nlm.nih.gov/pubmed/32742244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2139/ssrn.3652322
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