SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells

Acute lung injury (ALI), a common condition in critically ill patients, has limited treatments and high mortality. Aging is a risk factor for ALI. Sirtuins (SIRTs), central regulators of the aging process, decrease during normal aging and in aging-related diseases. We recently showed decreased SIRT7...

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Udgivet i:Sci Rep
Main Authors: Wyman, Anne E., Nguyen, Trang T. T., Karki, Pratap, Tulapurkar, Mohan E., Zhang, Chen-Ou, Kim, Junghyun, Feng, Theresa G., Dabo, Abdoulaye J., Todd, Nevins W., Luzina, Irina G., Geraghty, Patrick, Foronjy, Robert F., Hasday, Jeffrey D., Birukova, Anna A., Atamas, Sergei P., Birukov, Konstantin G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385158/
https://ncbi.nlm.nih.gov/pubmed/32719338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69236-z
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