Dissecting transcriptional amplification by MYC

Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier increasing output at all active promoters. Both models rest on large-scale genome-wide ”-omics’. Because the assumptions, stat...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nie, Zuqin, Guo, Chunhua, Das, Subhendu K, Chow, Carson C, Batchelor, Eric, Simons, S Stoney, Levens, David
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384857/
https://ncbi.nlm.nih.gov/pubmed/32715994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52483
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