Dissecting distinct proteolytic activities of FMDV L(pro) implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β) gene transcription. Multiple proteins in this signaling pathway (e.g. RIG-I, MDA5, MAVS, TBK1, IRF3...

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Publicat a:PLoS Pathog
Autors principals: Visser, Linda J., Aloise, Chiara, Swatek, Kirby N., Medina, Gisselle N., Olek, Karin M., Rabouw, Huib H., de Groot, Raoul J., Langereis, Martijn A., de los Santos, Teresa, Komander, David, Skern, Tim, van Kuppeveld, Frank J. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384677/
https://ncbi.nlm.nih.gov/pubmed/32667958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008702
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