Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn’s disease and active smoking status resulting in ileal stenosis requiring surgery

BACKGROUND: NOD2 variants are the strongest genetic predictors for susceptibility to Crohn’s disease (CD). However, the clinical value of NOD2 on an individual patient level remains controversial. We aimed to define the predictive power of the major NOD2 mutations regarding complicated CD in a large...

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Veröffentlicht in:PLoS One
Hauptverfasser: Schnitzler, Fabian, Friedrich, Matthias, Angelberger, Marianne, Diegelmann, Julia, Stallhofer, Johannes, Wolf, Christiane, Dütschler, Joel, Truniger, Samuel, Olszak, Torsten, Beigel, Florian, Tillack, Cornelia, Lohse, Peter, Brand, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384669/
https://ncbi.nlm.nih.gov/pubmed/32716958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236421
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