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Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart
The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) inflammasome. Thrombin antagonists reduce cardiac remodeling and dysfunction in diabetic mice, in part by suppressing fibrin-driven...
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| Veröffentlicht in: | Basic Res Cardiol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7384378/ https://ncbi.nlm.nih.gov/pubmed/31912235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-019-0771-9 |
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