Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex

Camptothecin (CPT) derivatives are clinically effective poisons of DNA topoisomerase I (Top1) able to form a ternary complex with the Top1–DNA complex. The aim of this investigation was to examine the dynamic aspects of the ternary complex formation by means of site-directed spin labeling electron p...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Ricci, Antonio, Marinello, Jessica, Bortolus, Marco, Sánchez, Albert, Grandas, Anna, Pedroso, Enrique, Pommier, Yves, Capranico, Giovanni, Maniero, Anna Lisa, Zagotto, Giuseppe
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384355/
https://ncbi.nlm.nih.gov/pubmed/21254781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101232t
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