Randomised clinical trial: linaclotide vs placebo—a study of bi‐directional gut and brain axis

BACKGROUND: Linaclotide, a guanylate cyclase C agonist relieves irritable bowel syndrome with predominant constipation (IBS‐C) symptoms, but how it improves pain in humans is unknown. AIMS: To investigate the effects of linaclotide and placebo on the afferent and efferent gut‐brain‐gut signalling in...

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Dades bibliogràfiques
Publicat a:Aliment Pharmacol Ther
Autors principals: Rao, Satish S.C., Xiang, Xuelian, Yan, Yun, Rattanakovit, Kulthep, Patcharatrakul, Tanisa, Parr, Rachael, Ayyala, Deepak, Sharma, Amol
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Randomised Clinical Trials
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384154/
https://ncbi.nlm.nih.gov/pubmed/32406112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.15772
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