Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis

Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and structural data for PFK from three human pathogenic trypanosomatids, illustrating intriguing differences that may reflect evolutionary adaptations t...

Full description

Saved in:
Bibliographic Details
Published in:FEBS J
Main Authors: Fernandes, Peter M., Kinkead, James, McNae, Iain W., Vásquez‐Valdivieso, Monserrat, Wear, Martin A., Michels, Paul A. M., Walkinshaw, Malcolm D.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383607/
https://ncbi.nlm.nih.gov/pubmed/31838765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15177
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items