Diversification of DNA-Binding Specificity by Permissive and Specificity-Switching Mutations in the ParB/Noc Protein Family

Specific interactions between proteins and DNA are essential to many biological processes. Yet, it remains unclear how the diversification in DNA-binding specificity was brought about, and the mutational paths that led to changes in specificity are unknown. Using a pair of evolutionarily related DNA...

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Publicat a:Cell Rep
Autors principals: Jalal, Adam S.B., Tran, Ngat T., Stevenson, Clare E., Chan, Elliot W., Lo, Rebecca, Tan, Xiao, Noy, Agnes, Lawson, David M., Le, Tung B.K.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383237/
https://ncbi.nlm.nih.gov/pubmed/32698006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107928
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