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Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS

OBJECTIVE: The aim of our research was to analyze and compare the pharmacokinetics of paeoniflorin, calycosin, calycosin-7-o-β-d-6-glucoside, and 6-gingerol in the blood and brain tissue of normal and cerebral ischemia-reperfusion injury rats by HPLC-MS/MS method. METHODS: The blood and brain tissue...

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Publicado en:Drug Des Devel Ther
Main Authors: Zheng, Hao-Zhen, Shen, Xiao, He, Ying-Ying, Yan, Xiang-Li, Wang, Sheng-Xin, Yu, Ai-Ming, Wang, Li-Sheng
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382588/
https://ncbi.nlm.nih.gov/pubmed/32764886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S257020
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